H157
Sigma

HOE 140

≥94%

Synonym

Icatibant acetate

D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg

Amino Acid Sequence

H₂N-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg

Molecular Formula

C₅₉H₈₉N₁₉O₁₃S

Molecular Weight

1304.52

CAS Number

138614-30-9

MDL number

MFCD00213940

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Descriptions

Biochem/physiol Actions

Selective B₂ bradykinin receptor antagonist.

Properties

assay

≥94%

storage temp.

−20°C

References

Reference

Feletou, et al., Agonistic and antagonistic properties of the bradykinin B₂ receptor antagonist HOE 140 in isolated blood vessels from different species. Br. J. Pharmacol. 112, 683-689, (1994) abstract

Wirth, et al., Hoe 140 a new potent and long acting bradykinin antagonist: In vivo studies. Br. J. Pharmacol. 102, 774-777, (1991) abstract

Trifilieff, et al., Effect of HOE 140, a new B₂ noncompetitive antagoniston guinea pig tracheal bradykinin receptors. J. Pharmacol. Exp. Ther. 263, 1377, (1992) abstract

Safety

WGK Germany