H4777
Sigma

Heparan sulfate proteoglycan

≥400 μg/mL glycosaminoglycan, sterile-filtered

Synonym

HSPG

MDL number

MFCD00283416

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Descriptions

Biochem/physiol Actions

Extracellular matrix component that binds to fibroblast growth factors, vascular endothelial growth factor (VEGF) and VEGF receptors through its sugar moiety. Acts as a docking molecule for matrilysin (MMP-7) and other matrix metalloproteinases.

Other Notes

Composed of a core protein covalently bound to heparan sulfate chains.

Properties

description

For cell culture use.

Isolated from basement membrane of Engelbreth-Holm-Swarm mouse sarcoma.

Solution in 50 mM Tris HCl, 150 mM NaCl, 1 mM EDTA, 0.1 mM PMSF, pH 7.4, containing ≥400 μg protein per ml.

sterility

sterile-filtered

form

solution

concentration

≥400 μg/mL glycosaminoglycan

total impurities

≥100 μg/mL Uronic acid

shipped in

dry ice

storage temp.

−20°C

References

Reference

Iozzo, R.V., and San Antonio, J.D., Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena. J. Clin. Invest. 108, 349-355, (2001)

Yu, W.H., and Woessner, J.F., Jr., Heparan sulfate proteoglycans as extracellular docking molecules for matrilysin (matrix metalloproteinase 7). J. Biol. Chem. 275, 4183-4191, (2000)

Nangia-Makker, P., et al. , Carbohydrate-recognition and angiogenesis.
. Cancer Metastasis Rev. 19, 51-57, (2000)

Safety

WGK Germany