H7629
Sigma

γ-Butyrolactone

≥99% (GC)

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Synonym

γ-Hydroxybutyric acid lactone

4-Hydroxybutyric acid lactone

GBL

Molecular Formula

C₄H₆O₂

Molecular Weight

86.09

CAS Number

96-48-0

Beilstein Registry Number

105248

MDL number

MFCD00005386

EG/EC Number

202-509-5

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Descriptions

Biochem/physiol Actions

Precursor of γ-hydroxybutyric acid (GHB). It blocks dopamine release by blocking impulse flow in dopaminergic neurons. Pretreatment with γ-butyrolactone allows detection of autoreceptor-induced dopamine release.

Properties

vapor density

3 (vs air)

vapor pressure

1.5 mmHg ( 20 °C)

assay

≥99% (GC)

autoignition temp.

851 °F

expl. lim.

16 %

refractive index

n20/D 1.436(lit.)

204-205 °C(lit.)

−45 °C(lit.)

density

1.12 g/mL at 25 °C(lit.)

storage temp.

2-8°C

References

Reference

Walters, J.R., and Roth, R.H., Dopaminergic neurons: drup-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow. J. Pharmacol. Exp. Ther. 191, 82-91, (1974)

Ohkawa, S., et al., Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives. J. Med. Chem. 34, 267-276, (1991)

Koeltzow, T.E., Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J. Neurosci. 18, 2231, (1998)

Merck

Merck 13,1596

Beilstein

Beil. 17,V,9,7

Fieser

Fieser 1,101

reference

Aldrich MSDS 1, 337:A / Arctander, 552 / Corp MSDS 1 (1), 656:A / FT-IR 2 (1), 1174:A / FT-IR 1 (1), 697:D / FT-NMR 1 (1), 1127:A / Fenaroli, 99 / IR-Spectra (3), 407:F / IR-Spectra (2), 360:H / NMR-Reference 2 (1), 590:C / RegBook 52 (1), 803:J / RegBook 1 (1), 803:J / Sax 6, 549 / Sigma FT-IR 1 (2), 623:A / Structure Index 1, 125:D:6 / Vapor Phase 3, 749:A

Safety

Hazard Codes

Risk Statements

22-36

Safety Statements

WGK Germany

RTECS

LU3500000

UEL

16.00%(V)

LEL

1.40%(V)