H7660
Sigma

Heregulin-β1 (EGF Domain) human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in Escherichia coli, lyophilized powder

Synonym

HRG-β1

MDL number

MFCD03457066

Expand/Collapse All

Descriptions

Analysis Note

The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.

Physical form

Lyophilized from a 0.2 μm filter with 2.5 mg bovine serum albumin.

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Properties

recombinant

expressed in Escherichia coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

predicted mol wt 8 kDa

total impurities

Endotoxin, tested

Gene Information

human ... NRG1(3084)

storage temp.

−20°C

References

Reference

Sundaresan S., The biology of human epidermal growth factor receptor 2. Curr. Oncol. Rep. 1, 16, (1999)

Karey, K.P., et al. Cancer Res. 48, 4083, (1988) abstract

Meyer, D., Birchmeier, C. Nature 378, 386, (1995)

Carraway, K. III J. Biol. Chem. 269, 14303, (1994)

Safety

Safety Statements

22-24/25

WGK Germany

3

Related Categories

... Hematopoietic Stem Cell Expansion/Differentiation > Cytokine/Growth Factor

... Receptor Tyrosine Kinases > Epidermal Growth Factor Receptor (EGFR)

... Tumor Growth Regulation > Epidermal Growth Factors

... Cytokines & Growth Factors > Epidermal Growth Factors (EGF)

... Epidermal Growth Factors (EGF) and NRG Family > Heregulin (HRG) and HRG Receptor

... Bioactives/Supplements > Proteins & Peptides

H7660 - Datasheet (82kb)

MSDS

Certificate of Analysis

Certificate of Origin

More Information

Related Categories

Printer Friendly View

Ask A Scientist

Last 5 Products Viewed

H7660 (Sigma)

Copyrights © 2008 Sigma-Aldrich Co. All Rights Reserved. Reproduction of any materials from the site is strictly forbidden without permission. Sigma-Aldrich brand products are sold exclusively through Sigma-Aldrich, Inc.