12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid 

Prometastatic metabolite of arachidonic acid via the 12-lipoxygenase pathway that is expressed in many tumor cell lines. It is produced in coronary microvasculature and is a potent inducer of relaxation and hyperpolarization of these microvessels. It activates large-conductance Ca²⁺-activated K⁺ currents in coronary microvascular smooth muscle.

Packaged under Argon.

12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.

≥95% (HPLC)

~100 μg/mL in ethanol

dry ice

−20°C

Zink, M.H., et al.,, 12-Lipoxygenase in porcine coronary microcirculation: implications for coronary vasoregulation. Am. J. Physiol. Heart Circ. Physiol. 280, H693-H704, (2001)

Hagmann, W., Lipoxygenase in human tumor cells. Pathol. Oncol. Res. 3, 83-88, (1997)

Szekeres, C.K., et al.,, Eicosanoid 12(S)-HETE activates phosphatidylinositol 3-kinase. Biochem. Biophys. Res. Commun. 275, 690-695, (2000)

F,Xi

11-36/37/38

7-16-26-36

UN 1170 3/PG 2

1

57 °F

14 °C

8-10-23