H7904
Sigma

4-Hydroxytamoxifen

≥98% (HPLC), powder

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Synonym

trans-4-Hydroxytamoxifen

(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol

Molecular Formula

C₂₆H₂₉NO₂

Molecular Weight

387.51

CAS Number

68047-06-3

MDL number

MFCD00278780

PubChem Substance ID

24895814

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Descriptions

Biochem/physiol Actions

Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation.

Properties

assay

≥98% (HPLC)

form

powder

color

white

solubility

95% ethanol: 20 mg/mL

Gene Information

rat ... Ar(24208), Esr1(24890), Esr2(25149)

human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569)

storage temp.

2-8°C

References

Reference

Kupfer, D., et al. Cancer Res. 54, 3140, (1994)

Manns, J.E., et al. Anal. Proc. 30, 161, (1993)

Murphy, C.S., et al. Mol. Pharmacol. 38, 737, (1991)

Custodio, J.B.A., et al. Biochem. Pharmacol. 47, 1989, (1994)

Safety

Hazard Codes

Risk Statements

20/21/22-63

Safety Statements

22-23-36

WGK Germany

RTECS

SL1210000

Related Categories

... Antibiotics A to Z > Antibiotics G-M

... Antibiotics by Application > Antineoplastic and Immunosuppressive Antibiotics

... Steroid Hormones > Other Steroid Products

... Protein Kinases and Phosphatases > Protein Kinase Inhibitors and Related Products

H7904 - Datasheet (60kb)

MSDS

Certificate of Analysis

Certificate of Origin

More Information