H9146
Sigma

13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid

~100 μg/mL in ethanol, ~98%

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Synonym

13(S)-HODE

Molecular Formula

C₁₈H₃₂O₃

Molecular Weight

296.44

CAS Number

29623-28-7

MDL number

MFCD00065833

PubChem Substance ID

24895844

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Descriptions

Biochem/physiol Actions

PPARγ agonist

Packaging

Packaged under Argon.

Biochem/physiol Actions

Expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13(S)-HODE, are decreased in human colorectal and esophageal cancers. Certain non-steroidal anti-inflammatory drugs (NSAIDs) can induce apoptosis in human colon cancer cells by increased expression of 15-LOX-1, which down-regulates PPAR-delta through 13-HODE.

Properties

assay

~98%

concentration

~100 μg/mL in ethanol

storage temp.

−20°C

References

Reference

Nagy, L., et al., Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell 93, 229-40, (1998)

Safety

Hazard Codes