H9538
Sigma

HNE-DMA

hexane solution, ≥85% (GC)

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Synonym

(E)-4-Hydroxynonenal-dimethylacetal

Molecular Formula

C₁₁H₂₂O₃

Molecular Weight

202.29

MDL number

MFCD07370138

PubChem Substance ID

24724506

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Descriptions

Biochem/physiol Actions

Stable form of HNE; toxic second messenger of free radicals.

Properties

assay

≥85% (GC)

form

hexane solution

shipped in

dry ice

storage temp.

−20°C

References

Reference

Liu, W., et al., Distict involvement of NF-KB and p39 metogen-activated protein kinase pathways in serum deprivation-mediated stimulation of inducible nitric oxide synthase and it inhibition by 4-hydroxynonenal. J. Cell Biol. 83, 271-280, (2001)

Hattori, Y., et al., 4-hydroxynonenal prevents NO production in vascular smooth muscle cells by inhiiting nuclear factor-KB-dependent transcriptional activation of inducible NO synthase. Arterioscler. Thromb. Vasc. Biol. 21, 1179-1183, (2001)

Picklo, M.J., et al., Carbonyl toxicology and Alzheimer's disease. Toxicol. Appl. Pharmacol. 184, 187-197, (2002)

Safety

Hazard Codes

F,Xn,N

Risk Statements

11-38-48/20-51/53-62-65-67

Safety Statements

36/37-61-62

RIDADR

UN 1208 3/PG 2

WGK Germany

Flash Point(F)