I2142
Sigma

KN-62

~95%, powder

1 of 1

Synonym

(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester

1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine

Molecular Formula

C₃₈H₃₅N₅O₆S₂

Molecular Weight

721.84

CAS Number

127191-97-3

MDL number

MFCD00083180

PubChem Substance ID

24895961

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Descriptions

Biochem/physiol Actions

Selectively inhibits rat brain Ca²⁺/calmodulin-dependent protein kinase II.

Properties

assay

~95%

form

powder

color

yellow

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL

methanol: 10 mg/mL

DMSO: 12 mg/mL

chloroform: 20 mg/mL

Gene Information

human ... P2RX7(5027)

storage temp.

−20°C

References

Reference

MacLeod, et al., Ca(2+)/Calmodulin kinase II and decreases in intracellular pH are required to activate K(+) channels after substantial swelling in villus epithelial cells. J. Membr. Biol. 172, 59-66, (1999) abstract

Fan, et al., Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Mol. Pharmacol. 56, 39-45, (1999) abstract

Communi, et al., Calcium-calmodulin-dependent protein kinase II and protein kinase C-mediated phosphorylation and activation of D-myo-inositol 145-trisphosphate 3-kinase B in astrocytes. J. Biol. Chem. 274, 14734-14742, (1999) abstract

Safety

WGK Germany

Related Categories

... Serine/Threonine Kinase Inhibitors > Calcium/Calmodulin-Dependent Protein Kinase (CaMK)

... A to C > Calmodulin dependent Protein Kinase II

... Enzyme Inhibitors > Calmodulin dependent Protein Kinase II

... P to Q > Protein Kinase II, Calmodulin dependent

... Kinase/Phosphatase Biology > Protein Kinase Inhibitors

... Protein Kinases and Phosphatases > Protein Kinase Inhibitors and Related Products

MSDS

Certificate of Analysis

Certificate of Origin

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