General description
A number of human and animal diseases have been found to result from mutations in the genes encoding ion channel proteins, and are referred to as channelopathies. This chronicles our understanding of the molecular basis of ion channel diseases. It includes the relevant aspects of molecular biology and biophysics and a description of methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.
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