I4125
Sigma

Inosine

≥99%

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Synonym

(−)-Inosine

Hypoxanthine 9-β-D-ribofuranoside

Molecular Formula

C₁₀H₁₂N₄O₅

Molecular Weight

268.23

CAS Number

58-63-9

Beilstein Registry Number

624896

MDL number

MFCD00066770

PubChem Substance ID

24896051

EG/EC Number

200-390-4

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Descriptions

Biochem/physiol Actions

Inosine is a potent stimulator of nerve growth factor (NGF) induced neurite outgrowth. The elevated levels of inosine in brain following injury are associated with the increased expression proteins related to axonal regeneration and growth. Mice given inosine demonstrated enhanced recovery of fine motor control following ischemic brain damage.

Properties

assay

≥99%

References

Reference

Chen, P., et al., Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc. Natl. Acad. Sci. USA 99, 9031, (2002) abstract

Benowitz, L.I. et al., Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proc. Natl. Acad. Sci. USA 96, 13486, (1999) abstract

Braumann, T., et al., Fate of cyclic nucleotides in PC12 cell cultures: uptake, metabolism, and effects of metabolites on nerve growth factor-induced neurite outgrowth. J. Neurochem. 47, 912, (1986) abstract

Safety

WGK Germany

RTECS

NM7460000

Related Categories

... Metabolites and Cofactors on the Metabolic Pathways Chart > Nucleotide

... Biochemicals Found in Plants > Other Biochemical

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

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