I4883
Sigma

Ibuprofen

≥98% (GC)

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Synonym

α-Methyl-4-(isobutyl)phenylacetic acid

Molecular Formula

C₁₃H₁₈O₂

Molecular Weight

206.28

CAS Number

15687-27-1

MDL number

MFCD00010393

PubChem Substance ID

24277715

EG/EC Number

239-784-6

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Descriptions

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Properties

assay

≥98% (GC)

Gene Information

human ... ALB(213), ALOX5(240), CYP1A2(1544), CYP2C9(1559), IL8RA(3577), PTGS1(5742), PTGS2(5743)

rat ... Alox5(25290), Ptgs1(24693)

mouse ... Alox5(11689)

References

Reference

Chen, C.S., et al., Metabolic stereoisomeric inversion of 2-arylpropionic acids. On the mechanism of ibuprofen epimerization in rats. Biochim. Biophys. Acta 1033, 1, (1990)

Barnett, J., et al., Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys. Acta 1209, 130, (1994)

Kato, M., et al., Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J. Pharm. Pharmacol. 53, 1679-1685, (2001)

Safety

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

RTECS

MU6640000