K0133
Sigma

Kaempferol

≥90% (HPLC), powder

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Synonym

3,4′,5,7-Tetrahydroxyflavone

3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Robigenin

Molecular Formula

C₁₅H₁₀O₆

Molecular Weight

286.24

CAS Number

520-18-3

Beilstein Registry Number

304401

MDL number

MFCD00016938

PubChem Substance ID

24896195

EG/EC Number

208-287-6

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Descriptions

Biochem/physiol Actions

A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation.¹ Inhibits topoisomerase I catalyzed DNA religation.²

Properties

assay

≥90% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

ethanol: 20 mg/mL

DMSO: 50 mg/mL

Gene Information

human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931)

mouse ... Hexa(15211)

storage temp.

Room temp

References

Cited Reference

1. Sahu, S.C. and Gray, G.C., Kaempferol-induced nuclear DNA damage and lipid peroxidation. Cancer Lett. 85, 159-164, (1994) abstract

2. Boege, F., et al., Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J. Biol. Chem. 271, 2262-2270, (1996) abstract

Reference

Lin, J.K., et al., Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J. Cell. Biochem. (Suppl.) 28-29, 39-48, (1997) abstract

Kuo, M.L., et al., Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine. Cancer Lett. 87, 91-97, (1994) abstract

Merck

Merck 13,5293

Beilstein

Beil. 18,V,5,251

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

LK9275200

8-10-23

Related Categories

... Chemopreventive Agents > Antioxidant and Free Radical Scavengers

... Biochemicals Found in Plants > Bioflavonoids

... Chemopreventive Agents > Phytoestrogens

... R to Z > Topoisomerase I

Nutrition biofiles7

MSDS

Certificate of Analysis

Certificate of Origin

More Information