K1265
Sigma

Ki8751 hydrate

≥98% (HPLC), solid

Synonym

1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea hydrate

Molecular Formula

C₂₄H₁₈F₃N₃O₄ · xH₂O

Molecular Weight

469.41 (anhydrous basis)

CAS Number

228559-41-9 (anhydrous)

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Descriptions

Biochem/physiol Actions

Ki8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC₅₀= 0.9 nM).

Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

References

Reference

Kubo, K., et al., Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas J. Med. Chem. 48, 1359-1366, (2005)

Safety

Hazard Codes

Risk Statements

22-38

Safety Statements

Related Categories

... Receptor Tyrosine Kinase Inhibitors > Vascular Endothelial Growth Factor Receptor (VEGFR)

MSDS

Certificate of Analysis

More Information

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