K4761
Sigma

TRAIL human

>95% (SDS-PAGE), recombinant, expressed in Escherichia coli, solution

Synonym

APO-2L

TNF-related apoptosis-inducing ligand

MDL number

MFCD01867158

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Descriptions

Biochem/physiol Actions

Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.

Physical form

Solution in 20 mM Hepes, pH 7.4, 300 mM sodium chloride, 0.01% Tween 20, 1% sucrose, and 0.1 mM DTT.

General description

Extracellular domain of human TRAIL (amino acids 95-281), fused at the N-terminus to a histidine-tag and a linker peptide.

Properties

recombinant

expressed in Escherichia coli

assay

>95% (SDS-PAGE)

form

solution

mol wt

mol wt 29 kDa by SDS-PAGE (reducing)

mol wt 32 kDa

Gene Information

human ... TNFSF10(8743)

shipped in

dry ice

storage temp.

−70°C

References

Reference

Dejosez M., et al., Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan. . Cell Death Differ. 7, 1127, (2000) abstract

Safety

WGK Germany

Related Categories

... Apoptosis and Cell Cycle > Death Receptor Ligands

Cytokine Receptors Tumor Necrosis Receptor Family (203 kb)

K4761 - Datasheet (53kb)

MSDS

Certificate of Analysis

Certificate of Origin

More Information