L0399
Sigma

Leuprolide acetate salt

≥98% (HPLC)

Synonym

des-Gly¹⁰-[D-Leu⁶]-LH-RH ethylamide

Leuprorelin

Amino Acid Sequence

pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt

Molecular Formula

C₅₉H₈₄N₁₆O₁₂ · xC₂H₄O₂

Molecular Weight

1209.40 (free base basis)

CAS Number

74381-53-6

MDL number

MFCD00167544

PubChem Substance ID

24896252

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Descriptions

Biochem/physiol Actions

Luteinizing hormone releasing hormone (LH-RH) agonist.

Properties

assay

≥98% (HPLC)

Gene Information

human ... GNRHR(2798)

rat ... Gnrhr(81668)

storage temp.

−20°C

References

Reference

Zheng, Y, et al., Permeability and absorption of leuprolide from various intestinal regions in rabbits and rats. Int. J. Pharmacol. 185, 83, (1999)

Imai, A., et al., Fas and Fas ligand system may mediate antiproliferative activity of gonadotropin-releasing hormone receptor in endometrial cancer cells. Int. J. Oncol. 13, 97-100, (1998) abstract

Ravivarapu, H.B., et al., Sustained suppression of pituitary-gonadal axis with an injectable, in situ forming implant of leuprolide acetate. J. Pharm. Sci. 89, 732-741, (2000) abstract

Goto, T., et al., Gonadotropin-releasing hormone agonist has the ability to induce increased matrix metalloproteinase (MMP)-2 and membrane type 1-MMP expression in corpora lutea, and structural luteolysis in rats. J. Endocrinol. 161, 393-402, (1999) abstract

Ogawa, T., et al., Leuprolide, a gonadotropin-releasing hormone agonist, enhances colonization after spermatogonial transplantation into mouse testes. Cell 30, 583-588, (1998)

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

OH6390000