L0517
Sigma

Leukotriene B₄

~100 μg/mL in ethanol, ≥97%

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Synonym

[5S,12R]-Dihydroxy-[6Z,8E,10E,14Z]-eicosatetraenoic acid

Molecular Formula

C₂₀H₃₂O₄

Molecular Weight

336.47

CAS Number

71160-24-2

MDL number

MFCD00135630

PubChem Substance ID

24896256

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Descriptions

Biochem/physiol Actions

Proinflammatory agent. Stimulates c-Fos and c-Jun proto-oncogene transcription in human monocytes. Stimulates chemotaxis, aggregation, and degranulation of polymorphonuclear leukocytes.

Packaging

Data sheet which accompanies each product includes special handling instructions. Except where noted, method for hydrolysis of methyl esters is also described.

Properties

assay

≥97%

concentration

~100 μg/mL in ethanol

shipped in

dry ice

storage temp.

−20°C

References

Reference

Ford-Hutchinson, A.W., Leukotriene B₄ in inflammation. Crit. Rev. Immunol. 10, 1-12, (1990) abstract

Dokter, W.H., et al., Interleukin-4-mediated inhibition of C-Fos mRNA expression: role of the lipoxygenase directed pathway. Leukemia 8, 1181-1184, (1994) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

7-16

RIDADR

UN 1170 3/PG 2

WGK Germany

UEL

19.00%

LEL

3.30%