L109
Sigma

Lorglumide sodium salt

solid

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Synonym

CR 1409

(±)-4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoic acid sodium salt

Molecular Formula

C₂₂H₃₁Cl₂N₂NaO₄

Molecular Weight

481.39

CAS Number

97964-56-2

MDL number

MFCD00083183

PubChem Substance ID

24278098

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Descriptions

Biochem/physiol Actions

Potent and selective non-peptide cholecystokinin (CCK_A) receptor antagonist; orally active.

Properties

form

solid

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >10 mg/mL

H₂O: 10 mg/mL

methanol: 28 mg/mL

Gene Information

human ... CCKAR(886)

References

Reference

Makovec, F., et al., Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists. Arzneimittelforschung 37, 1265-1268, (1987) abstract

D'Amato, M., et al., Studies of three non-peptide cholecystokinin antagonists (devazepide lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum. Br. J. Pharmacol. 102, 391-395, (1991) abstract

Edwards, G.L., and Power, J.D., The role of brain-gut peptides in the control of sodium appetite. Ann. N.Y. Acad. Sci. 897, 192-197, (1999) abstract

Safety

WGK Germany

RTECS

SA3680700