L134
Sigma

Linopirdine

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Synonym

1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one

DuP 996

Molecular Formula

C₂₆H₂₁N₃O

Molecular Weight

391.46

CAS Number

105431-72-9

MDL number

MFCD00867216

PubChem Substance ID

24277846

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Descriptions

Biochem/physiol Actions

Stimulates release of acetylcholine and other neurotransmitters; cognitive enhancer.

Legal Information

Sold under exclusive license from the DuPont Merck Pharmaceutical Company.

Properties

color

white or off-white

solubility

ethanol: 240 mg/mL

H₂O: insoluble

Gene Information

rat ... Kcnj1(24521)

References

Reference

Aiken, S.P., Zaczek, R., Brown, B.S., Pharmacology of the neurotransmitter release enhancer linopirdine (DuP 996), and insights into its mechanism of action. Adv. Pharmacol. 35, 349-384, (1996) abstract

Tam, S.W., Zaczek, R., Linopirdine. A depolarization-activated releaser of transmitters for treatment of dementia. Adv. Exp. Med. Biol. 363, 45-56, (1995)

Maciag, et al., Studies on the role of K⁺Cl^- and Na⁺ ion permeabilities in the acetylcholine release enhancing effects of linopirdine (DuP 996) in rat cortical slices. J. Pharmacol. Exp. Ther. 271, 891-897, (1994) abstract

Safety

WGK Germany