L137
Sigma

L-733,060 hydrochloride

solid, ≥98% (HPLC)

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Synonym

(2S,3S)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride

Molecular Formula

C₂₀H₁₉F₆NO · HCl

Molecular Weight

439.82

CAS Number

148687-76-7

MDL number

MFCD01862671

PubChem Substance ID

24278530

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Descriptions

Biochem/physiol Actions

Non-peptide NK₁ tachykinin receptor antagonist; selective for guinea pig/human versus rat/mouse.

Legal Information

Manufactured and sold under license from Merck, Sharp and Dohme Ltd.

Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL

H₂O: insoluble

Gene Information

human ... TACR1(6869)

storage temp.

2-8°C

References

Reference

Kramer, M., et al., Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281, 1640, (1998) abstract

Rupniak, N., et al., Enantioselective inhibition of the formalin paw late phase by the NK₁ receptor antagonist L-733,060 in gerbils. Pain 67, 189, (1996) abstract

Seabrook, G., et al., L-733,060a novel tachykinin NK receptor antagonist: effects in [Ca²⁺] immobilisation cardiovascular and dural extravasation assays. Eur. J. Pharmacol. 317, 129, (1996) abstract

Safety

WGK Germany

Related Categories

... Neuropeptides > Tachykinins

MSDS

Certificate of Analysis

More Information

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L137 (Sigma)