L5011
Sigma

Leukotriene D₄

~50 μg/mL in methanol: water (7:3) containing 17 mM acetate buffer adjusted to pH 5.4 with NH₄OH, ~97%

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Molecular Formula

C₂₅H₄₀N₂O₆S

Molecular Weight

496.66

CAS Number

73836-78-9

MDL number

MFCD00036839

PubChem Substance ID

24896383

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Descriptions

Biochem/physiol Actions

Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca²⁺ in epithelial cells.

Packaging

Packaged under argon.

Properties

assay

~97%

concentration

~50 μg/mL in methanol: water (7:3) containing 17 mM acetate buffer adjusted to pH 5.4 with NH₄OH

shipped in

dry ice

storage temp.

−70°C

References

Reference

Piper, P., Formation and actions of leukotrienes. Physiol. Rev. 64, 744, (1984) abstract

Sjolander, A., Leukotriene D₄ and E₄ induce transmembrane signaling in human epithelial cells. Single cell analysis reveals diverse pathways at the G-protein level for the influx and the intracellular mobilization of Ca²⁺. J. Biol. Chem. 265, 20976, (1990) abstract

Samuelsson, B., Leukotrienes and lipoxins: structures biosynthesis and biological effects. Science 237, 1171, (1987) abstract

Safety

Hazard Codes

F,T

Risk Statements

11-23/24/25-39/23/24/25

Safety Statements

7-16-36/37-45

RIDADR

UN 1230 3/PG 2

WGK Germany