L7134
Sigma

Luteinizing hormone releasing hormone human acetate salt

≥98% (HPLC), powder

Synonym

Gonadoliberin

Gonadotropin releasing hormone

LH-RH

Amino Acid Sequence

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

Molecular Formula

C₅₅H₇₅N₁₇O₁₃

Molecular Weight

1182.29

CAS Number

71447-49-9

MDL number

MFCD00133489

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Descriptions

Components

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

Other Notes

free peptide

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

Properties

assay

≥98% (HPLC)

form

powder

mol wt

M_r 1182.33

Gene Information

human ... GNRH1(2796)

storage temp.

−20°C

References

Reference

Imai, A., and Tamaya, T., GnRH receptor and apoptotic signaling. Vitam. Horm. 59, 1-33, (2000) abstract

Ortmann, O., and Diedrich, K., Pituitary and extrapituitary actions of gonadotrophin-releasing hormone and its analogues. Hum. Reprod. 14, 194-206, (1999) abstract

Shacham, S., et al., Mechanism of GnRH receptor signaling: from the membrane to the nucleus. Ann. Endocrinol. 60, 79-88, (1999)

Safety

Hazard Codes

Risk Statements

Safety Statements

53-45

WGK Germany

RTECS

OK6470000

10-21

Related Categories

... Tumor Growth Regulation > Androgen Modulators

... Releasing Factors > LH-RH

... Antitumor Agents > Therapy Adjuncts

MSDS

Specification Sheet

Certificate of Analysis

More Information