Limonin 

Limonin is a triterpenoid aglycone that is a bitter principle of citrus fruits. It has anti-proliferative, proapoptotic activity on several cancer cell lines and inhibits azoxymethane-induced colon cancer in rats. It also inhibits HIV-1 replication in culturedf monocytes, macrophages, and mononuclear cells, perhaps by inhibition of HIV-1 protease activity.

from citrus seeds

>90% (HPLC)

2-8°C

Poulose, S.M., et al., Antiproliferative effects of citrus limonoids against human neuroblastoma and colonic adenocarcinoma cells. Nutr. Cancer 56, 103-112, (2006)

Roy, A., and Saraf, S., Limonoids: overview of significant bioactive triterpenes distributed in plants kingdom. Biol. Pharm. Bull. 29, 191-201, (2006)

Vanamala, J., et al., Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis 27, 1257-1265, (2006)

Tian, Q., et al., Differential inhibition of human cancer cell proliferation by citrus limonoids. Nutr. Cancer 40, 180-184, (2001)

Battinelli, L., et al., Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells. Planta Med. 69, 910-913, (2003)

Merck 13,5516

3