L9908
Sigma

LY-294,002 hydrochloride

solid, ≥98% (HPLC)

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Synonym

2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride

Molecular Formula

C₁₉H₁₇NO₃ · HCl

Molecular Weight

343.80

CAS Number

934389-88-5

MDL number

MFCD00270881

PubChem Substance ID

24278828

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Descriptions

Biochem/physiol Actions

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Properties

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >5 mg/mL

H₂O: insoluble

storage temp.

2-8°C

References

Reference

Vlahos, C.J., et al., A specific inhibitor of phosphatidylinositol 3-kinase 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241, (1994) abstract

Vlahos, C.J., et al., Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154, 2413-2422, (1995) abstract

Brunn, G.J., et al., Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 15, 5256-5267, (1996) abstract

Safety

WGK Germany