M1314
Sigma

Mer/Fc Chimera human

>90% (SDS-PAGE), recombinant, expressed in Sf21 cells, lyophilized powder

MDL number

MFCD03457463

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Descriptions

Analysis Note

Measured by its ability to bind recombinant human Gas6.

Biochem/physiol Actions

This receptor binds the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which induces receptor autophosphorylation and downstream signaling pathways leading to cell proliferation, migration, or the prevention of apoptosis.

General description

Extracellular domain of human Mer (amino acids 1-499) fused to the C-terminal Fc region of human IgG1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Properties

recombinant

expressed in Sf21 cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 78.9 kDa

mol wt 100-110 kDa by SDS-PAGE (reducing)

total impurities

endotoxin, tested

Gene Information

human ... MERTK(10461)

storage temp.

−20°C

References

Reference

Graham, D.K., Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell. Growth Differ. 5, 647, (1994) abstract

Nagata, K., et al., Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J. Biol. Chem. 271, 30022, (1996) abstract

Safety

WGK Germany