M2011
Sigma

Melphalan

powder

zoom

1 of 1

Synonym

4-[Bis(2-chloroethyl)amino]-L-phenylalanine

L-PAM

L-Phenylalanine mustard

Molecular Formula

C₁₃H₁₈Cl₂N₂O₂

Molecular Weight

305.20

CAS Number

148-82-3

Beilstein Registry Number

2816456

MDL number

MFCD00057717

PubChem Substance ID

24278538

EG/EC Number

205-726-3

Expand/Collapse All

Descriptions

Biochem/physiol Actions

Antineoplastic agent.^1,² It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences.³

Properties

form

powder

color

white

References

Cited Reference

1. Nawata, S., et al., Isolated lung perfusion with melphalan for the treatment of metastatic pulmonary sarcoma. J. Thorac. Cardiovasc. Surg. 112, 1542-1548, (1996)

2. Orlandi, L., et al., Effect of melphalan and hyperthermia on p34^cdc2 kinase activity in human melanoma cells. Br. J. Cancer 74, 1924-1928, (1996) abstract

3. Bauer, G.B. and Povirk, L.F., Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res. 25, 1211-1218, (1997) abstract

Merck

Merck 13,5850

Beilstein

Beil. 14,IV,1689

Safety

Hazard Codes

T+

Risk Statements

45-46-26/27/28-63

Safety Statements

53-22-36/37/39-45

RIDADR