M2939
Sigma

Methyl arachidonyl fluorophosphonate

≥98%, methyl acetate solution

Synonym

MAPF

Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester

Molecular Formula

C₂₁H₃₆FO₂P

Molecular Weight

370.48

MDL number

MFCD03095722

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Descriptions

Biochem/physiol Actions

MAFP is a selective, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic phospholipase A₂, but not secretory phospholipase A₂. MAFP is also a potent acetylcholinesterase inhibitor.

Preparation Note

To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.

Properties

assay

≥98%

form

methyl acetate solution

shipped in

dry ice

storage temp.

−70°C

References

Reference

Balsinde, J., Dennis, E.A., Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages. J. Biol. Chem. 271, 6758, (1996)

Lio, Y-C., Irreversible inhibition of Ca⁺²-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim. Biophys. Acta 1302, 55, (1996)

Safety

Hazard Codes

F,Xi

Risk Statements

11-36-66-67

Safety Statements

16-26-29-33

RIDADR

UN 1231 3/PG 2

WGK Germany

Flash Point(F)

3 °F