M3262
Sigma

N-Methyl-D-aspartic acid

≥98% (titration), solid

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Synonym

(R)-2-(Methylamino)succinic acid

NMDA

Molecular Formula

C₅H₉NO₄

Molecular Weight

147.13

CAS Number

6384-92-5

Beilstein Registry Number

1724431

MDL number

MFCD00004226

PubChem Substance ID

24277987

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Descriptions

Biochem/physiol Actions

Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.

Properties

assay

≥98% (titration)

form

solid

color

white

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

rat ... Gria1(50592), Grik1(29559), Grin2a(24409)

References

Reference

Manfridi, A., et al., Stimulation of NMDA and AMPA receptors in the rat nucleus basalis of Meynert affects sleep. Am. J. Physiol. 277, R1488, (1999) abstract

Collingridge, G. L., et al., Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40, 143-210, (1989)

Hansen, J. J., et al., Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors. Med. Res. Rev. 10, 55-94, (1990) abstract

Cain, D. P., Testing the NMDA, long-term potentiation, and cholinergic hypotheses of spatial learning. Neurosci. Biobehav. Rev. 22, 181, (1998) abstract

Merck

Merck 13,6696

Beilstein

Beil. 4,III,1522

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

CI9457000