M3819
Sigma

MCA-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys(DNP)-NH₂ trifluoroacetate salt

≥95% (HPLC), powder

Synonym

MCA-HQKLVFFAK(DNP)-NH₂

Molecular Formula

C₇₃H₉₄N₁₆O₁₉ · xC₂HF₃O₂

Molecular Weight

1499.62 (free base basis)

MDL number

MFCD07776909

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Descriptions

Biochem/physiol Actions

α-Secretase substrate I, fluorogenic.

Properties

assay

≥95% (HPLC)

form

powder

color

yellow

shipped in

wet ice

storage temp.

−20°C

References

Reference

Kowalewski, T., and Holtzman, D.M., In situ atomic force microscopy study of Alzheimer's beta-amyloid peptide on different substrates: new insights into mechanism of beta-sheet formation. Proc. Natl. Acad. Sci. USA 96, 3688-3693, (1999) abstract

Farzan, M., et al., BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc. Natl. Acad. Sci. USA 97, 9712-9717, (2000) abstract

Safety

WGK Germany