Melatonin 

Solutions are light sensitive and subject to oxidation.

Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

≥98% (HPLC)

powder

off-white

116.5-118 °C(lit.)

H₂O: 0.1 mg/mL

ethanol: 8 mg/mL

human ... MTNR1A(4543), MTNR1B(4544), NOS1(4842), NOS2A(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

−20°C

Reiter, R.J., et al., Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington's disease, Alzheimer's disease and parkinsonism. Ann. N.Y. Acad. Sci. 890, 471-485, (1999) abstract

Cuzzocrea, S, et al., The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat. FASEB J. 13, 1930, (1999) abstract

Sanchez-Barcelo, E.J., et al., Melatonin and mammary cancer: a short review. Endocrinol. Relat. Cancer 10, 153-159, (2003)

Sainz, R.M., et al., Melatonin and cell death: differential actions on apoptosis in normal and cancer cells. Cell. Mol. Life Sci. 60, 1407-1426, (2003) abstract

Goldman, B.D., The circadian timing system and reproduction in mammals. Steroids 64, 679, (1999) abstract

Merck 13,5838

Beil. 22,V,12,42

FT-IR 2 (3), 3606:D / FT-IR 1 (2), 677:A / FT-NMR 1 (3), 156:C / IR-Spectra (3), 1260:A / IR-Spectra (2), 1095:G / NMR-Reference 2 (2), 546:C / RegBook 1 (2), 2421:A / Sigma FT-IR 1 (1), 678:D / Structure Index 1, 384:D:3

2

AC5955000