M5273
Sigma

Monensin sodium salt

90-95% (TLC)

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Synonym

Monensin A sodium salt

Molecular Formula

C₃₆H₆₁NaO₁₁

Molecular Weight

692.85

CAS Number

22373-78-0

Beilstein Registry Number

4122200

MDL number

MFCD00077826

PubChem Substance ID

24896992

EG/EC Number

244-941-7

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Descriptions

Biochem/physiol Actions

Na⁺ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

Properties

assay

90-95% (TLC)

storage temp.

2-8°C

References

Reference

Callaway, T.R., et al., Selection of a highly monensin-resistant Prevotella bryantii subpopulation with altered outer membrane characteristics. Appl. Environ. Microbiol. 65, 4753-4759, (1999) abstract

Wang, X.D., et al., Phospholipase C activation by Na⁺/Ca²⁺ exchange is essential for monensin-induced Ca²⁺ influx and arachidonic acid release in FRTL-5 thyroid cells. J. Investig. Med. 47, 388-396, (1999) abstract

Nebbia, C., et al., Oxidative metabolism of monensin in rat liver microsomes and interactions with tiamulin and other chemotherapeutic agents: evidence for the involvement of cytochrome P-450 3A subfamily. Drug Metab. Dispos. 27, 1039-1044, (1999) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

36/37/39-45

RIDADR

UN 3462 6.1/PG 2

WGK Germany

RTECS

JH2830000

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