M5518
Sigma

Mezerein

from Daphne mezereum, ≥97% (HPLC)

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Synonym

12β-[(E,E)-5-Phenyl-2,4-pentadienoyloxy]daphnetoxin

Molecular Formula

C₃₈H₃₈O₁₀

Molecular Weight

654.70

CAS Number

34807-41-5

Beilstein Registry Number

1675867

MDL number

MFCD00135953

PubChem Substance ID

24897019

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Descriptions

Biochem/physiol Actions

Potent second stage tumor promotor and inflammatory agent; activates protein kinase C at nanomolar concentrations.

Other Notes

Phorbol ester analog from the plant Daphne mezereum.

Properties

biological source

from Daphne mezereum

assay

≥97% (HPLC)

storage temp.

−20°C

References

Reference

O'Brian, C.A., and Ward, N.E., Biology of the protein kinase C family. Cancer Metastasis Rev. 8, 199-214, (1989) abstract

Madireddi, M.T., et al., AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation. J. Cell Physiol. 185, 36-46, (2000) abstract

Rehman, I., et al., Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N'-nitro-N-nitrosoguanidine and promoted by mezerein. Mol. Carcinog. 27, 298-307, (2000) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

22-24/25

WGK Germany

RTECS

HB5425500

10-21

Related Categories

... Protein Phosphorylation > Protein Kinase Activators

... Tumor Growth Regulation > Tumor Promotors

MSDS

Specification Sheet

Certificate of Analysis

More Information