M5560
Sigma

(S)-2-Amino-2-methyl-4-phosphonobutyric acid hydrochloride

synthetic, solid

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Synonym

(S)-MAP4 hydrochloride

MDL number

MFCD00672650

PubChem Substance ID

24277822

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Descriptions

Biochem/physiol Actions

Selective mGluR_4,6,7 metabotropic glutamate receptor antagonist.

Properties

biological source

synthetic

form

solid

color

white

Gene Information

human ... GRM4(2914), GRM6(2916), GRM7(2917)

References

Reference

Knopfel T, et al., Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes. Neuropharmacology 34, 1099-1102, (1995) abstract

Salt, T.E. and Eaton, S.A., Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65, 5, (1995) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany