Immunogen
synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-3 (stromelysin-1).
Specificity
Reacts with reduced and to a lesser extent non-reduced MMP-3. The propeptide is shed after activation; therefore, the antibody recognizes the pro-form of MMP-3 and not the active forms. May be used to distinguish the latent from the active form of MMP-3. Recognizes Stromelysin-1 and Stromelysin-2, but not Stromelysin-3 or other MMP family members.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.