M6680
Sigma

Se-(Methyl)selenocysteine hydrochloride

≥95% (TLC)

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Molecular Formula

C₄H₉NO₂Se · HCl

Molecular Weight

218.54

CAS Number

26046-90-2

MDL number

MFCD03412451

PubChem Substance ID

24278564

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Descriptions

Biochem/physiol Actions

Chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture.

Properties

assay

≥95% (TLC)

storage temp.

−20°C

References

Reference

Ip, C., et al., New concepts in selenium chemoprevention. Cancer Metastasis Rev. 21, 281-289, (2002)

Spallholz, J.E., et al., Dimethyldiselenide and methylseleninic acid generate superoxide in an in vitro chemiluminescence assay in the presence of glutathione: implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine. Nutr. Cancer 40, 34-41, (2001)

Whanger, P.D., Selenium and its relationship to cancer: an update dagger. Br. J. Nutr. 91, 11-28, (2004)

Yeo, J.K., et al., Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 182, 83-92, (2002)

Safety

Hazard Codes

T,N

Risk Statements

23/25-33-50/53

Safety Statements

20/21-28-45-60-61

RIDADR

UN 3283 6.1/PG 2

WGK Germany