M6817
Sigma

Monoclonal Anti-Minor Vault Protein 193 antibody produced in mouse

250 μg/mL, clone p193-6, tissue culture supernatant

Synonym

Anti-p193

Anti-VPARP

MDL number

MFCD03791745

Expand/Collapse All

Descriptions

Immunogen

E. coli lysate transformed with the pET28a(+) expression vector containing amino acids 408-611 of the p193 cDNA.

Specificity

Reacts with an internal epitope (aa 593-599, FSKVEDY) of p193.

Physical form

Supplied in serum-free culture medium containing 0.7% bovine serum albulin and 0.1% sodium azide.

Properties

antibody form

tissue culture supernatant

clone

p193-6

species reactivity

human

concentration

250 μg/mL

application(s)

immunoblotting (chemiluminescent): 1:10-1:20

immunocytochemistry: 1:10-1:20 using 4% paraformaldehyde-fixed cytospin preparations

immunohistochemistry (frozen sections): 1:10-1:20

isotype

IgG2bκ

Gene Information

human ... PARP4(143)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Schroeijers, A.B., et al., The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines. Cancer Res. 60, 1104-1110, (2000)

Kickhoefer, V.A., et al., The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J. Cell Biol. 146, 917-928, (1999)

Scheper, R.J., et al., Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res. 53, 1475-1479, (1993)

Scheffer, G.L., et al., The drug resistance-related protein LRP is the human major vault protein. Nat. Med. 1, 578-582, (1993)

Kickhoefer, V.A., et al., Vaults are up-regulated in multidrug-resistant cancer cell lines. J. Biol. Chem. 273, 8971-8974, (1998)

Safety

WGK Germany

Related Categories

... Antibodies for Multi-Drug Resistance > Antibodies to Other MDR-related Proteins

... Multidrug Resistance > Multidrug Resistance Antibodies

... M > Other

... Clone Index > P

M6817 - Datasheet (30kb)

MSDS

Certificate of Analysis

More Information