M7067
Sigma

Monoclonal Anti-Major Vault Protein antibody produced in mouse

250 μg/mL, clone LRP-56, tissue culture supernatant

Synonym

Anti-LRP

Anti-Lung Resistance Protein

Anti-MVP

MDL number

MFCD01633598

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Descriptions

Immunogen

drug resistant tumor cell line SW-1573/2R120.

Specificity

Reacts with an internal epitope of LRP/MVP (P110).

Physical form

Supplied in serum-free culture medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Properties

antibody form

tissue culture supernatant

clone

LRP-56

mol wt

antigen mol wt ~110 kDa

species reactivity

human

concentration

250 μg/mL

application(s)

flow cytometry: suitable

immunocytochemistry: 1:20 using air-dried or acetone-fixed cells

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:20

immunohistochemistry (frozen sections): 1:20

Gene Information

human ... MVP(9961)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Izquierdo, M.A., et al., Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma. J. Natl. Cancer Inst. 87, 1230-1237, (1995) abstract

List, A.F., et al., Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood 87, 2464-2469, (1996) abstract

Den Boer, M.L., et al. , Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia. Leukemia 11, 1078-1085, (1997) abstract

Schroeijers, A.B., et al., The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines. Cancer Res. 60, 1104-1110, (2000)

Kickhoefer, V.A., et al., Vaults are up-regulated in multidrug-resistant cancer cell lines. J. Biol. Chem. 273, 8971-8974, (1998)

Scheffer, G.L., et al., The drug resistance-related protein LRP is the human major vault protein. Nat. Med. 1, 578-582, (1995)

Scheper, R.J., et al., Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res. 53, 1475-1479, (1993)

Kickhoefer, V.A., et al., The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J. Cell Biol. 146, 917-928, (1999)

Schroeijers, A.B., et al., Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues. Am. J. Pathol. 152, 373-378, (1998) abstract

Stein, U., et al., Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP. J. Natl. Cancer Inst. 89, 807-813, (1997) abstract

Schadendorf, D., et al., Membrane transport proteins associated with drug resistance expressed in human melanoma. Am. J. Pathol. 147, 1545-1552, (1995) abstract

Izquierdo, M.A., et al. , Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am. J. Pathol. 148, 877-887, (1996) abstract

Safety

WGK Germany

Related Categories

... Cancer Markers and Antibodies > Antibodies

... Antibodies for Multi-Drug Resistance > Antibodies to Other MDR-related Proteins

... Clone Index > L

... Multidrug Resistance > Multidrug Resistance Antibodies

... M > Other

M7067 - Datasheet (28kb)

MSDS

Certificate of Analysis

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