M8046
Sigma

Mifepristone

≥98%

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1 of 1

Synonym

11β-(4-Dimethylamino)phenyl-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one

RU-38486

RU-486

Molecular Formula

C₂₉H₃₅NO₂

Molecular Weight

429.59

CAS Number

84371-65-3

MDL number

MFCD00867226

PubChem Substance ID

24278572

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Descriptions

Biochem/physiol Actions

Progesterone receptor antagonist; stimulates prolactin secretion. Pgp inhibitor.

Properties

assay

≥98%

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), PGR(5241)

storage temp.

2-8°C

References

Reference

Skinner, D.C., et al. J. Neuroendocrinol. 11, 637, (1999) abstract

Lecureur, V., et al., The antiprogestatin drug RU 486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P-glycoprotein function. FEBS Lett. 355, 187-194, (1994)

Reilly, P.E., et al. Chem. Biol. Interact. 118, 39, (1999) abstract

Thomas, A., et al. J. Neuroendocrinol. 11, 137, (1999) abstract

Payen, L., et al., Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486. Biochem. Biophys. Res. Commun. 258, 513-518, (1999) abstract

Lucci, A., et al., Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells. Int. J. Oncol. 15, 535-540, (1999) abstract

Safety

Hazard Codes

Risk Statements

60-61

Safety Statements

53-22-36/37/39-45

WGK Germany

RTECS

KG2955000