N1019
Sigma

(−)-Nicotine hemisulfate salt

≥95% (TLC), ~40 % (w/v) in H₂O (based on free base)

Synonym

(−)-1-Methyl-2-(3-pyridyl)pyrrolidine

Molecular Formula

(C₁₀H₁₄N₂)₂ · H₂SO₄

Molecular Weight

422.54

CAS Number

65-30-5

MDL number

MFCD00148918

PubChem Substance ID

24897454

EG/EC Number

200-606-7

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Descriptions

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Caution

Shelf-life of the solution as supplied is at least six years when stored at room temperature.

Quality

Mixture of nicotine base and nicotine sulfate.

Properties

assay

≥95% (TLC)

concentration

~40 % (w/v) in H₂O (based on free base)

color

brown

References

Reference

Sihver, W., et al., Autoradiographic comparison of [³H](-)nicotine, [³H]cytisine and [³H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease. Neuroscience 94, 685-696, (1999)

Haass, M., and Kubler, W., Nicotine and sympathetic neurotransmission. Cardiovasc. Drugs Ther. 10, 657-665, (1997)

Brioni, J.D., et al., The pharmacology of (−)-nicotine and novel cholinergic channel modulators. Adv. Pharmacol. 37, 153-214, (1997) abstract

Lena, C., and Changeux, J.P., Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders. Curr. Opin. Neurobiol. 7, 674-682, (1997) abstract

Girod, R., et al., Heteromeric complexes of α5 and/or α7 subunits. Effects of calcium and potential role in nicotine-induced presynaptic facilitation. Ann. N.Y. Acad. Sci. 868, 578-590, (1999) abstract

Safety

Hazard Codes

T+

Risk Statements

24/25-26-36/37/38-63

Safety Statements

26-28-36/37/39-45

RIDADR

UN 1658 6.1/PG 2

RTECS

QS9625000

Related Categories

... Cholinergics > Agonists

... Biochemicals Found in Plants > Alkaloid

... Pesticides > Others

MSDS

Certificate of Analysis

Certificate of Origin

More Information

(−)-Nicotine hemisulfate salt

≥95% (TLC), ~40 % (w/v) in H2O (based on free base)

≥95% (TLC), ~40 % (w/v) in H₂O (based on free base)