N142
Sigma

NO-711 hydrochloride

solid, ≥98% (HPLC)

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Synonym

1-[2-[[(Diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride hydrochloride

Molecular Formula

C₂₁H₂₂N₂O₃ · HCl

Molecular Weight

386.87

CAS Number

145645-62-1

MDL number

MFCD00153853

PubChem Substance ID

24278817

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Descriptions

Biochem/physiol Actions

Potent and selective GABA uptake inhibitor that crosses the blood-brain barrier.

Caution

Photosensitive

Properties

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

solubility

H₂O: ≥10 mg/mL at 60 °C

Gene Information

human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

References

Reference

Nielsen, et al., Characterization of tiagibine (NO-328) a new potent and selective GABA uptake inhibitor. Eur. J. Pharmacol. 196, 257, (1991) abstract

Dong, et al., GABA transporters and GABA_C-like receptors on catfish cone - but not rod-driven horizontal cells. J. Neurosci. 14, 2648, (1994) abstract

Suzdak, et al., NNC-711 a novel potent and selective γ-aminobutyric acid uptake inhibitor: Pharmacological characterization. Eur. J. Pharmacol. 203, 189, (1992)

Safety

WGK Germany

Related Categories

... Ligand-Gated Ion Channels > GABA and Glycine Receptor Modulators

... GABAergics > Others

MSDS

Certificate of Analysis

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