N171
Sigma

NBQX hydrate

solid, ≥98% (HPLC)

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Synonym

FG 9202

1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate

Molecular Formula

C₁₂H₈N₄O₆S � xH₂O

Molecular Weight

336.28 (anhydrous basis)

CAS Number

118876-58-7 (anhydrous)

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Descriptions

Biochem/physiol Actions

Neuroprotective AMPA/kainate glutamate receptor antagonist.

Properties

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

methanol: 0.25 mg/mL

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.5 mg/mL

DMSO: 4 mg/mL

H₂O: insoluble

References

Reference

Lees, et al., Differential effects of NBQX on the distal and local toxicity of glutamate agonists administered intra-hippocampally. Brain Res. 628, 1-7, (1993) abstract

Randle, et al., Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro-substitution. Eur. J. Pharmacol. 215, 237, (1992)

Overgaard, et al., Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke. Neurol. Res. 15, 344-349, (1993) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany