N194
Sigma

NS-398

≥98% (HPLC), solid

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Synonym

N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide

Molecular Formula

C₁₃H₁₈N₂O₅S

Molecular Weight

314.36

CAS Number

123653-11-2

MDL number

MFCD00882995

PubChem Substance ID

24897540

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Descriptions

Biochem/physiol Actions

Selective cyclooxygenase-2 (COX-2) inhibitor.

Properties

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >5 mg/mL

H₂O: insoluble

Gene Information

human ... ALOX5(240), CYP19A1(1588), PTGS1(5742), PTGS2(5743)

mouse ... Ptgs2(19225)

References

Reference

Yamamoto, T., and Nozaki-Taguchi, N., Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor. Brain Res. 739, 104-110, (1996) abstract

Coffey, et al., Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-basolateral release of prostaglandins and mitogenesis in polarizing colon cancer cells. Proc. Natl. Acad. Sci. USA 94, 657, (1997) abstract

Futaki, et al., NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47, 55-59, (1994) abstract

Safety

Safety Statements

22-24/25

WGK Germany