N2404
Sigma

Neurophysin I from bovine pituitary

CAS Number

63231-59-4

MDL number

Descriptions

Biochem/physiol Actions

Mutations leading to disruptions of the structure and/or conformation of neurophysins are implicated in the pathophysiology of central diabetes insipidus (CDI).

Other Notes

Protein found in vasopressin- and oxytocin-containing neurons in the hypothalamus that is associated with the transport of these hormones to the posterior pituitary.

Properties

mol wt

mol wt ~10 kDa

storage temp.

2-8°C

References

Reference

de Bree, F.M. and Burbach, J., Structure-function relationships of the vasopressin prohormone domains. Cell. Mol. Neurobiol. 18, 173, (1998) abstract

Legros, J.J., and Geenen, V., Neurophysins in central diabetes insipidus. Horm. Res. 45, 182-186, (1996) abstract

Kim, J.K. and Schrier, R.W., Vasopressin processing defects in the Brattleboro rat: implications for hereditary central diabetes insipidus in humans?. Proc. Assoc. Am. Physicians 110, 380-386, (1998) abstract

Audhya,TK., and Walter, R., Highly purified neurophysin proteins: method of isolation based on their acidic properties. Arch. Biochem. Biophys. 180, 130-139, (1977)

Kazmierkiewicz, R., et al., Elucidation of neurophysin/bioligand interactions from molecular modeling. Acta Biochim. Pol. 44, 453-466, (1997) abstract

Safety

WGK Germany

Related Categories

... Neurobiology > Neural Proteins

MSDS

Certificate of Analysis

Certificate of Origin

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