N3266
Sigma

Neuropeptide Y porcine

≥97% (HPLC), synthetic

Synonym

NPY

Amino Acid Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH₂

Molecular Formula

C₁₉₀H₂₈₇N₅₅O₅₇

Molecular Weight

4253.65

CAS Number

83589-17-7

MDL number

MFCD00131713

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Descriptions

Biochem/physiol Actions

Vasoconstrictor; brain peptide that inhibits Ca²⁺-activated K⁺ channels in vascular smooth muscle. Implicated in the control of blood pressure, sexual behavior and food intake. Inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

Properties

biological source

synthetic

assay

≥97% (HPLC)

Gene Information

pig ... NPY(397304)

storage temp.

−20°C

References

Reference

Colmers, W.F., and Bleakman, D., Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. 17, 373-379, (1994)

Sun, L., et al., Regulation of K⁺ and Ca²⁺ channels by a family of neuropeptide Y receptors. J. Pharmacol. Exp. Ther. 284, 625, (1998)

Holst, J.J., et al., On the regulatory functions of neuropeptide Y (NPY) with respect to vascular resistance and exocrine and endocrine secretion in the pig pancreas. Acta Physiol. Scand. 136, 519-526, (1989)

Beech, D.J., Actions of neurotransmitters and other messengers on Ca²⁺ channels and K⁺ channels in smooth muscle cells. Pharmacol. Ther. 73, 91, (1997)

Kalra, S.P., and Horvath, T.L., Neuroendocrine interactions between galanin, opioids, and neuropeptide Y in the control of reproduction and appetite. Ann. N.Y. Acad. Sci. 863, 236-240, (1998)

Billington, C.J., and Levine, A.S., Hypothalamic neuropeptide Y regulation of feeding and energy metabolism. Curr. Opin. Neurobiol. 2, 847-851, (1992)

Safety

WGK Germany

10-21

Related Categories

... Gastrointestinal Peptides > Neuropeptide Y

... Neuropeptide Y and Peptide YY Peptides > Neuropeptide Y

... Neurotransmission (Obesity) > Neuropeptide Y and Peptide YY

... Obesity Peptides > Y Receptor Ligands

MSDS

Specification Sheet

Certificate of Analysis

More Information