N3529
Sigma

NAN-190 hydrobromide

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Synonym

1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide

Molecular Formula

C₂₃H₂₇N₃O₃ � HBr

Molecular Weight

474.39

CAS Number

115338-32-4

MDL number

MFCD00467878

PubChem Substance ID

24278108

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Descriptions

Biochem/physiol Actions

Potent 5-HT_1A serotonin receptor antagonist active in the nM range.

Properties

Gene Information

human ... HTR1A(3350)

References

Reference

Rydelek-Fitzgerald, L., et al., NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors. Brain Res. 532, 191-196, (1990) abstract

Yamada, K., et al., 5-Hydroxytryptamine-induced outward currents mediated via 5-HT(1A) receptors in neurons of the rat dorsolateral septal nucleus. J. Neurosci. Res. 37, 307-314, (2000)

Paluchowska, M.H., et al., On the bioactive conformation of NAN-190 (1) and MP3022 (2)5-HT(1A) receptor antagonists. J. Med. Chem. 42, 4952-4960, (1999) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany