N4143
Sigma

Neurokinin B

≥95% (HPLC)

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Synonym

β-Neurokinin

Neuromedin K

Amino Acid Sequence

Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH₂

Molecular Formula

C₅₅H₇₉N₁₃O₁₄S₂

Molecular Weight

1210.42

CAS Number

86933-75-7

MDL number

MFCD00133665

PubChem Substance ID

24897694

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Descriptions

Biochem/physiol Actions

Endogenous tachykinin agonist with preference for the NK-3 receptor. Potent bronchoconstrictor; may have neuromodulatory role in brain.

Properties

assay

≥95% (HPLC)

storage temp.

−20°C

References

Reference

Koutcherov, Y., et al., The distribution of the neurokinin B receptor in the human and rat hypothalamus. Neuroreport 11, 3127-3131, (2000) abstract

Lecci, A., et al., In vivo effects of neurokinin B on rat urinary bladder motility: involvement of tachykinin NK1 and NK2 receptors. Neuropeptides 27, 53-62, (1994) abstract

Daoui, S., et al., Neurokinin B- and specific tachykinin NK(3) receptor agonists-induced airway hyperresponsiveness in the guinea-pig. Br. J. Pharmacol. 130, 49-56, (2000) abstract

Safety

WGK Germany

Related Categories

... Tachykinins > Agonist

... Neuropeptides > Tachykinins

MSDS

Certificate of Analysis

More Information