N4286
Sigma

NU2058

>98% (HPLC)

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Synonym

O6-Cyclohexylmethylguanine

Molecular Formula

C₁₂H₁₇N₅O

Molecular Weight

247.30

CAS Number

161058-83-9

MDL number

MFCD05664734

PubChem Substance ID

24724549

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Descriptions

Biochem/physiol Actions

Selective cyclin-dependent kinase-2 (CDK2) inhibitor.

Properties

assay

>98% (HPLC)

color

white

solubility

DMSO: 22 mg/mL

H₂O: soluble

storage temp.

2-8°C

References

Reference

Gibson, A. E., et al, Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J. Med. Chem. 45, 3381-3393 , (2002)

Knockaert, M., et al, Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol. Sci. 23, 417-425, (2002)

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany