N4766
Sigma

N-Nitroso-N-methylurea

Bulk package

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1 of 1

Synonym

MNU

N-Methyl-N-nitrosourea

Molecular Formula

C₂H₅N₃O₂

Molecular Weight

103.08

CAS Number

684-93-5

MDL number

MFCD00014794

PubChem Substance ID

24897712

EG/EC Number

211-678-4

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Descriptions

Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.

Packaging

Weight on dry basis.

Properties

contains

aqueous acetic acid as stabilizer

storage temp.

2-8°C

References

Reference

Stephanou, G., et al., A comparative study on the effect of MNU on human lymphocyte cultures in vitro evaluated by O⁶-mdG formation, micronuclei and sister chromatid exchanges induction. Cancer Lett. 109, 109-114, (1996)

Engelbergs, J., et al., Role of DNA repair in carcinogen-induced ras mutation. Mutat. Res. 450, 139-153, (2000)

Laduca, J.R., and Sinha, D.K., Tumorigenesis of rat mammary epithelial cells by N-nitroso-N-methylurea in an in vitro system: characterization of the microtumors. Cancer Lett. 32, 204-210, (1996)

Safety

Hazard Codes

F,T

Risk Statements

45-46-61-11-25

Safety Statements

53-45

RIDADR

UN 1325 4.1/PG 2

WGK Germany

RTECS

YT7875000