N5636
Sigma

3-Nitropropionic acid

≥97%

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Molecular Formula

O₂N(CH₂)₂CO₂H

Molecular Weight

119.08

CAS Number

504-88-1

Beilstein Registry Number

1759889

MDL number

MFCD00007406

PubChem Substance ID

24278593

EG/EC Number

208-003-0

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Descriptions

Biochem/physiol Actions

Excitotoxin shown to cause brain lesions similar to those of Huntington's disease.

Properties

assay

≥97%

68-70 °C(lit.)

solubility

alcohol: 100 mg/mL, may be light yellow

storage temp.

2-8°C

References

Reference

Kim, G.W., et al., Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid. J. Cereb. Blood Flow Metab. 20, 119-129, (2000) abstract

Schulz, J.B., et al., The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases. Mol. Cell Biochem. 174, 193-197, (1997) abstract

Cooper, J.M., and Schapira, A.H., Mitochondrial dysfunction in neurodegeneration. J. Bioenerg. Biomembr. 29, 175-183, (1997) abstract

Beilstein

Beil. 2,IV,771

reference

Aldrich MSDS 1, 1377:C / Corp MSDS 1 (2), 2594:B / FT-IR 2 (1), 822:A / FT-IR 1 (1), 543:D / IR-Spectra (3), 320:F / IR-Spectra (2), 251:G / RegBook 1 (1), 575:G / Sax 6, 2040 / Sigma FT-IR 1 (2), 795:D / Structure Index 1, 82:A:6

Safety

Hazard Codes

Risk Statements

25-36/37/38

Safety Statements

26-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

UF6220000