N_ω-Nitro-L-arginine methyl ester hydrochloride 

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An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodilation when used to pretreat aortic ring preparations of mice. Induces leukocyte adhesion and increases microvascular fluid and protein fluxes and permeability. It has also been used in many studies of learning and memory.

≥98% (TLC)

powder

white to off-white

H₂O: 50 mg/mL

−20°C

Rees, D.D., et al., Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101, 746-752, (1990) abstract

Kubes, P., et al., Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 88, 4651-4655, (1991) abstract

Kubes, P., and Granger, D.N., Nitric oxide modulates microvascular permeability. Am. J. Physiol. 262, H611-H615, (1992) abstract

Nakamura, T., et al., Lecithinized superoxide dismutase induces vasodilation; evidence of direct contribution of superoxide anions to modulating vascular tone. Life Sci. 64, PL65-PL70, (1999) abstract

Haul, S., et al., Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase. J. Neurophysiol. 81, 494-497, (1999) abstract

Zou, L.B., et al., Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats. Neuropharmacology 37, 323-330, (1998) abstract

Knepper, B.R., and Kurylo, D.D., Effects of nitric oxide synthase inhibitor N^G-nitro-L-arginine methyl ester on spatial and cued learning. Neuroscience 83, 837-841, (1998) abstract

Beil. 4,IV,2650

22-24/25

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